Although the nerve auto graft still remains the clinical Gold standard in repairing nerve injury gaps, many advances have been achieved to guide regenerating axons across the lesion. Functional recovery after peripheral nerve lesion is depended upon accurate regeneration of axons to their original target tissues. To increase the prospects of axonal regeneration and functional recovery, researches have focused on designing “Nerve guidance channels” or NGCs. NGCs are either natural or synthetic tubular conduits that are used to bridge the gap between injured nerve stumps. This review paper describes peripheal nerve regeneration on NGCs.

Although more than two decades has passed since the first peripheral never repair, unfortunately good result of peripheral nerve repair is still less that 50%. Seddan classification of never injury is still the best classification. In this article, we will review never degeneration, regeneration, technic of neurorraphy, material for repair of the nerve and how to evaluate the result of repair. At the end the result of neurorraphy will be discussed.

Introduction: Facial paralysis is a devastating condition with profound functional, aesthetic and psychosocial consequences. Tumors within or outside the skull, Bell’s palsy and trauma are the most common causes of facial paralysis in adults.Case Presentation: Our patient was a 35-year-old man with deep laceration wounds. The patient was taken to the operating room and the nerves were repaired. We observed gradual improvement of muscle performance except branches of the frontal nerve.Conclusions: Complete rupture of the facial nerve is challenging and the treatment is surgery, which requires careful planning.

BACKGROUND Preventing perineural adhesions and scars formation in the traumatic peripheral injuries is very important on the recovery process. We aimed to evaluate the effect of using the amniotic membrane wrapping on the results of surgical treatment of damaged peripheral nerves. METHODS This cohort study included 30 patients with symptoms of acute peripheral nerve injuries due to penetrating trauma in the forearm or wrist in January 2019 to November 2020 referred to the Hand and Microsurgery Department, 15 Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. In 15 patients, after nerve repair, amniotic membrane coverage was used around the nerve, all patients were followed for 12 months. Ultrasound study for neuroma formation and nerve regeneration was determined based on EMG and NCV findings. The modified Medical Research Councile classification (MRCC) was used to evaluate of motor and sensory recovery. RESULTS In the amniotic membrane wrapping group, all patients had nerve regeneration and functional nerve recovery occurred after 12 months. In the control group, 5 patients (33. 4%) did not have nerve recovery and had functional and sensory impairment. In terms of functional capabilities,there was a significant difference in pinch strength, grip power and MRCC scoring between the two groups. Moreover, the mean volume of neuroma in these patients who used amniotic membrane covering was 2. 7 mm3 and in the control group, it was 3. 9 mm3 (P=0. 001). Five patients who did not have a damaged nerve, the neuroma volume was 4. 8 ±,0. 9 mm3. CONCLUSION The use of amniotic membrane covering is effective methods in the improve results of peripheral nerve repair and nerve function recovery.